Genetic Mutations Support The Stanton Migraine Protocol®
Sharing a recently published article. It explains the genetic foundation to all of my work and discovery of the ionic pump issues associated with migraines at the voltage gated sodium-potassium channels and ATPhase which is associated with mutations in the glucose metabolism processes.
The article is technical with a lot of jargon but the title tells it all
“ATP1A2 Mutations in Migraine: Seeing through the Facets of an Ion Pump onto the Neurobiology of Disease”
It discusses hyper sensory organ sensitivity, the mutation of voltage gated pumps that migraineurs need to use extra salt in their diet for. It also provides a genetic mutation base for the glucose intolerance migraineurs seem to have. It is an open access article, so if you are interested and familiar with the terminology, chew your way through it!
My hypothesis, based on which the Stanton Migraine Protocol® is built and the book “Fighting The Migraine Epidemic: How To Treat and Prevent Migraines Without Medicines – An Insider’s View” is written, is provided a solid genetic foundation 2+ years after I published my book and started to treat migraineurs. Very grateful and happy!
Now we know the genetics behind why migraineurs using the Stanton Migraine Protocol® are so successful at becoming and staying migraine and medicine free: we took control of the very channels that have genetic mutations and control the ionic process with precision.
Please contact me for more information!
About Angela A Stanton, Ph.D.
Angela A Stanton, PhD, is a Neuroeconomist focusing on chronic pain--migraine in particular--physiology, electrolyte homeostasis, nutrition, and genetics. She lives in Southern California. Her current research is focused on migraine cause, prevention, and treatment without the use of medicine. As a forever migraineur from childhood, her discovery was helped by experimenting on herself. She found the cause of migraine to be at the ionic level, associated with disruption of the electrolyte homeostasis, resulting from genetic variations of all voltage dependent channels, gates, and pumps (chanelopathy) that modulate electrolyte mineral density and voltage in the brain. In addition, insulin and glucose transporters, and several other variants, such as MTHFR variants of B vitamin methylation process and many others are different in the case of a migraineur from the general population.
Migraineurs are glucose sensitive (carbohydrate intolerant) and should avoid eating carbs as much as possible. She is working on her hypothesis that migraine is a metabolic disease.
As a result of the success of the first edition of her book and her helping over 5000 migraineurs successfully prevent their migraines world wide, all ages and both genders, and all types of migraines, she published the 2nd (extended) edition of her migraine book "Fighting The Migraine Epidemic: Complete Guide: How To Treat & Prevent Migraines Without Medications". The 2nd edition is the “holy grail” of migraine cause, development, and prevention, incorporating all there is to know. It includes a long section for medical and research professionals. The book is full of academic citations (over 800) to authenticate the statements she makes to make it easy to follow up by those interested and to spark further research interest. It is a "Complete Guide", published on September 29, 2017.
Dr. Stanton received her BSc at UCLA in Mathematics, MBA at UCR, MS in Management Science and Engineering at Stanford University, PhD in Economics with dissertation in neuroscience (culminating in Neuroeconomics) at Claremont Graduate University, fMRI certification at Harvard University Medical School at the Martinos Center for Neuroimaging for experimenting with neurotransmitters on human volunteers, certification in LCHF/ketogenic diet from NN (Nutrition Network), certification in physiology (UPEN via Coursea), Nutrition (Harvard Shool of Public Health) and functional medicine studies. Dr. Stanton is an avid sports fan, currently power weight lifting and kickboxing. For relaxation (yeah.. about a half minute each day), she paints and photographs and loves to spend time with her family of husband of 45 years, 2 sons and their wives, and 2 granddaughters.
Follow her on Twitter at: @MigraineBook, LinkedIn at https://www.linkedin.com/in/angelaastantonphd/ and facebook at https://www.facebook.com/DrAngelaAStanton/
For those with 23andme and other genetic testing of their genome what SNP’s and what variation type are they claiming to be the cause of migraine types?
“To date, about 81 ATP1A2 mutations have been reported in migraine-correlated neurological disease cases in the literature. A complete list is provided in Supplementary Table 1”
Which is not provided or available in supplemental information! I do not access to studies as a some academics do just what is on the web and I spent a bit of time trying to find ATP1A info but there is nothing specific as I suspect it is conjecture as this time as also mentioned in the study.
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Stuart, I preset for you the Human Database already set for Migraine: https://www.genecards.org/Search/Keyword?queryString=migraine&pageSize=-1&startPage=0 The ATP1A2 score is much higher now and is #1. Note: migraine (as other conditions) are being mapped as we speak. By no means do we have a complete picture yet. The trick is to understand what this variants (variants showing up via genetics by the way, doesn’t mean they have been activated so they may not be functioning as variants) actually mean.
ATP1A2 is responsible for “ATPase Na+/K+” as you can read on the database I am sending you to. This refers to the voltage dependent sodium/potassium pumps that operate via ATPase (ATP attached to magnesium molecule to open the gates). With this variant, migraineurs are electrolyte challenged and end up with dysregulation. It is the same in ALL migraine types. Migraine is caused by one thing for all migraine types.
I explain that in great detail in my book “Fighting The Migraine Epidemic: Complete Guide: How To Treat & Prevent Migraines Without Medications” that is available everywhere but e-book only on amazon. Here is the amazon source to both e-book and paperback: https://www.amazon.com/Fighting-Migraine-Epidemic-Migraines-Medications-ebook/dp/B076BZG2V3/ref=sr_1_1?ie=UTF8&qid=1518636023&sr=8-1&keywords=fighting+the+migraine+epidemic
It is an almost 700-page book. The genetics are explained in Part IV for medical professionals and scientists.